In One United Nations, the organizations of the system committed themselves to a more unified, purposeful United Nations system working towards shared goals in a common endeavour to maximize the impact of their support to Member States. The setting up of the High-level Panel on United Nations System-wide Coherence is timely. It dovetails with the system’s own efforts and comes at a time of renewal and change within the system. The organizations of the system look forward to an outcome of the Panel’s work that will make a significant contribution to advancing the coherence and effectiveness of the system’s response to the multifaceted challenges confronting the international community.